Noxians (from the city/state Noxus) are one of the major factions in the fantasy world related to the game League of Legends. They are sort of evil/brutal compared to for example Demacians (from the city/state Demacia) which are not in good terms between them, even warring against them, at least in the past. Noxians stand under the principle that only strong survive, and consider qualities of benevolence and compassion as signs of weakness.
Ezreal, who is a rather peaceful, neutral explorer and an archaeologist, has this quote: "Noxians... I hate those guys."
I just took Ezreal to a new place, taking a cold advance, and giving Noxus (in the background) a present in a form of Trueshot Barrage (Where Ezreal fires a wave of magic missiles with an arcane bow/glove), which is sort of his signature "move" in the actual game.
If you haven't played League of Legends (and have developed an interest), it is a free to play game with millions of players around the globe.